Sylvie G Bernier Selected Research

PPI 2458

3/2007	Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458.
4/2006	Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
7/2004	A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.

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Sylvie G Bernier Research Topics

Disease

8	Inflammation (Inflammations) 09/2021 - 10/2003
3	Fibrosis (Cirrhosis) 01/2020 - 01/2018
2	Heart Failure 01/2020 - 01/2018
2	Diabetic Nephropathies (Diabetic Nephropathy) 01/2020 - 01/2018
2	Rheumatoid Arthritis 01/2015 - 07/2004
2	Arthritis (Polyarthritis) 03/2007 - 07/2004
2	Neoplasms (Cancer) 04/2006 - 10/2003
1	Neuroinflammatory Diseases 09/2021
1	Pulmonary Hypertension 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021
1	Drug-Related Side Effects and Adverse Reactions 01/2021
1	Sickle Cell Anemia (Hemoglobin S Disease) 01/2021
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020
1	Non-alcoholic Fatty Liver Disease 01/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2019
1	Liver Diseases (Liver Disease) 01/2019
1	Proteinuria 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Hypertension (High Blood Pressure) 01/2018
1	Ureteral Obstruction 01/2018
1	Castleman Disease (Castleman's Disease) 01/2015
1	Multiple Sclerosis 10/2013
1	Hypersensitivity (Allergy) 09/2013
1	Pain (Aches) 09/2013
1	Lymphopenia (Lymphocytopenia) 04/2009
1	Osteitis 03/2007
1	Bone Resorption 03/2007
1	Experimental Arthritis 03/2007
1	Melanoma (Melanoma, Malignant) 04/2006
1	Carcinoma (Carcinomatosis) 08/2005
1	Chronic Disease (Chronic Diseases) 07/2004
1	Seizures (Absence Seizure) 07/2004
1	Hepatocellular Carcinoma (Hepatoma) 10/2003
1	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 04/2003
1	Necrosis 10/2002
1	Hyperemia 05/2002
1	Hypercapnia 05/2002
1	Acidosis 05/2002

Drug/Important Bio-Agent (IBA)

7	Soluble Guanylyl CyclaseIBA 09/2021 - 01/2018
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2021 - 01/2018
4	Methionine (L-Methionine)FDA Link 03/2007 - 07/2004
3	PPI 2458IBA 03/2007 - 07/2004
2	LipopolysaccharidesIBA 09/2021 - 01/2018
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2019
2	SaltsIBA 01/2020 - 01/2018
2	praliciguatIBA 01/2019 - 01/2018
2	AminopeptidasesIBA 03/2007 - 08/2005
2	Peptidoglycan (Murein)IBA 03/2007 - 07/2004
2	Polysaccharides (Glycans)IBA 03/2007 - 07/2004
2	methionine aminopeptidase 2IBA 04/2006 - 08/2005
2	Proteins (Proteins, Gene)FDA Link 08/2005 - 05/2002
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 09/2021
1	Neuroprotective AgentsIBA 09/2021
1	Quinolinic AcidIBA 09/2021
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2021
1	Carboxylic AcidsIBA 01/2021
1	Donepezil (Aricept)FDA LinkGeneric 01/2021
1	GlucuronidesIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	CholesterolIBA 01/2020
1	Triglycerides (Triacylglycerol)IBA 01/2020
1	ElementsIBA 01/2019
1	azasteneIBA 01/2018
1	CytokinesIBA 01/2018
1	Interleukin-6 (Interleukin 6)IBA 01/2015
1	ProdrugsIBA 10/2013
1	Sphingosine-1-Phosphate ReceptorsIBA 10/2013
1	Amino AlcoholsIBA 10/2013
1	Guanylate Cyclase (Guanylyl Cyclase)IBA 09/2013
1	Sulfonic AcidsIBA 09/2013
1	uroguanylinIBA 09/2013
1	guanylinIBA 09/2013
1	Hormones (Hormone)IBA 09/2013
1	EstersIBA 03/2007
1	carbamic acid (ammonium carbamate)IBA 03/2007
1	EnzymesIBA 04/2006
1	fumagillinIBA 04/2006
1	Small Interfering RNA (siRNA)IBA 08/2005
1	O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)IBA 07/2004
1	Pharmaceutical PreparationsIBA 07/2004
1	AntibodiesIBA 10/2003
1	lysophosphatidic acidIBA 10/2003
1	Oxidants (Oxidizing Agents)IBA 04/2003
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 10/2002
1	Caspase InhibitorsIBA 10/2002
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2002
1	benzoylcarbonyl- aspartyl- glutamyl- valyl- aspartyl- fluoromethyl ketoneIBA 10/2002
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 10/2002
1	Niacinamide (Nicotinamide)FDA LinkGeneric 10/2002
1	Retinaldehyde (Retinal)IBA 05/2002
1	Prostaglandins EIBA 05/2002
1	NADPH Dehydrogenase (Dehydrogenase, NADP)IBA 05/2002
1	NADP (NADPH)IBA 05/2002
1	ProstaglandinsIBA 05/2002
1	NitritesIBA 05/2002

Therapy/Procedure

1	Therapeutics 01/2019
1	Oral Administration 04/2009
1	Molecular Targeted Therapy 03/2007
1	Microspheres (Microsphere) 05/2002